NMR SPECTROSCOPY IDENTIFIES CHEMICALS IN CIGARETTE SMOKE CONDENSATE THAT IMPAIR SKELETAL MUSCLE MITOCHONDRIAL FUNCTION

NMR Spectroscopy Identifies Chemicals in Cigarette Smoke Condensate That Impair Skeletal Muscle Mitochondrial Function

Tobacco smoke-related diseases such as chronic obstructive pulmonary disease (COPD) are associated with high healthcare burden and mortality rates.Many COPD patients were reported to have muscle atrophy and weakness, with several studies suggesting intrinsic muscle mitochondrial impairment as a possible driver of this phenotype.Whereas much informa

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Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal cancer (mCRC).Owing to the lack of established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments.Moreover, conventional chemotherapy regime

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Learning to Read Big Books: Dante, Spenser, Milton

The interpretive challenges posed by dense and lengthy poems such as Dante’s Inferno, Spenser’s Faerie Queene, and Milton’s Paradise Lost can prove daunting for the average undergraduate reader whose experience of texts has been circumscribed by pedagogical mandates focused on reading for information.While information-retrieval ba

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